Oprah in Talks to Do '30' Rock

(WireImage.com)

Oprah Winfrey's ever expanding empire could soon replace the stars as the "final frontier."

E! is reporting the talk show queen is close to signing a deal to appear on NBC's hit show, 30 Rock. Winfrey will guest star on an episode this fall, tentatively set to air Nov. 6. So far, the plan is to have her play herself opposite Tina Fey's character, Liz Lemon.

Winfrey's character may also play into a feud between Tracy Jordan (Tracy Morgan) and Jenna Maroney (Jane Krakowski) that will continue through several episodes.